Meet John Doe had its workshop premiere at the New York Musical Theater Fesitival (NYMF) in 2004 and was selected as part of the National Alliance for Musical Theatre convention in 2005. In 2006 it was presented in a limited production at the Goodspeed Opera House. In 2007, it received its world premiere at the Ford's Theatre in Washington, D.C., starring Heidi Blickenstaff and Jim Moye and directed by Eric Schaeffer. The production was nominated for 7 Helen Hayes Awards; Schaeffer and Blickenstaff both took home awards.

In 2011, Porchlight Music Theatre in Chicago presented the Midwest premiere. The production opened March 4, 2011 at the Theater Building Chicago and ran for six weeks.